Image of the Month

A view of the Badab-e Surt. Mazandaran Province in northern Iran. The stepped travertine terrace formations that created over thousands of years as flowing water from two mineral springs (Photo by :Anahita Sadeghi MD)


The collection of articles appearing in the current book consists of manuscripts on the history of medicine in Iran, initially published from 1998 to 2014 in the “Archives of Iranian Medicine” (AIM). These articles are categorized into four separate parts, based on their subjects: Part 1) Ancient Times, Medieval Period, Part 2) Contemporary Medicine, Part 3) Outstanding Physicians and Part 4) Historical Background of Fatal Diseases in Iran. These 73 manuscripts have now been compiled in a 446 pages book for those who are interested in the history of Iranian medicine.

Since the Archive of Iranian Medicine (AIM) journal presents as Open Access monthly, online periodical from May 2013, thus dear readers may refer to the journal website ( for free downloading of the published papers.

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A Monthly Peer-Reviewed Medical Journal Published by the Academy of Medical Sciences of the I.R. Iran; Indexed in PubMed/MEDLINE, ISI Web of Science, EMBASE, SCOPUS, CINHAL, PASCAL, CSA, SID, ISSN: Print 1029-2977, Online 1735-3947.The impact factor of Archives of Iranian Medicine according to Journal Citation Reports®(JCR®) 2012 is 1.222.

Selected Article
Serum Osteoprotegerin in Relation to Metabolic Status, Severity, and Estimated Risk of Subsequent Coronary Heart Disease 1

Authors' affiliations: 1Endocrinology and Metabolism Research Center (EMRC),Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, 2Department of Cardiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

•Corresponding author and reprints: Alireza Esteghamati MD, Professor of Endocrinology and Metabolism, Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P. O. Box 13145-784, Tehran, Iran. Tel: (+9821)-88417918, Fax: (+9821)-64432466, E-mail:

Accepted for publication: 20 June 2014


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Authors: *Alireza Esteghamati1, Sara Sheikhbahaei2, Nima Hafezi-Nejad3, Mostafa Mousavizadeh4, Sina Noshad5, Naser Gilani Larimi6, Reyhaneh Azizi7, Manouchehr Nakhjavani8,
Keywords: Biological markers, blood, cardiac imaging, coronary heart diseases, osteoprotegerin

BACKGROUND: Osteoprotegerin (OPG), a key factor in bone remodeling and vascular calcification, has been suggested to be associated with cardiovascular events. This study sought to assess the relationship between plasma OPG, anthropometric, metabolic status, severity and extent of coronary artery calcification, and the two-year recurrence risk of coronary event in patients with coronary heart disease (CHD).
METHODS: A total of 155 consecutive patients with symptoms suggestive of CHD were enrolled in this cross-sectional study. Blood samples were taken for laboratory tests. Coronary angiography and cardiac CT scan were performed to assess the severity and extent of involved vessels. Two-year risk of subsequent CHD was estimated based on the computational Framingham risk prediction model.
RESULTS: OPG level was in direct linear association with age (β = 0.38, p < 0.001), waist to hip ratio (β = 0.17, p < 0.05), hs-CRP (β = 0.17, p < 0.05), systolic and diastolic blood pressure (β = 0.17, p < 0.05; β = 0.23, p < 0.01), and HbA1c (β = 0.17, p < 0.05). After age-sex adjustment, only HbA1c (β = 0.15, p < 0.05) was a significant indicator of serum OPG. OPG showed significant linear association with the coronary calcium score (CCS), and the number of involved vessels even after adjustment for age, sex, diabetes, blood pressure, and markers of bone-calcium metabolism (β = 0.27, P < 0.05; β = 29, P < 0.01). There is a significant positive association between two-year risk of subsequent CHD and serum OPG in females (β = 0.45, P < 0.01) but not in males.
CONCLUSION: Increased OPG is independently associated with the severity and extent of CHD. This study also proposes OPG as a potential marker in predicting the risk of subsequent CHD, in females.

ISSN:1029-2977       Article type:Original


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