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A view of the central desert of Iran ( Kavir-e Lut),Kalut ,Shahdad- Kerman Province, these  geological features created by wind erosion over years.(Photo by :M.H.Azizi MD)


Announcement

Since the Archive of Iranian Medicine (AIM) journal presents as Open Access monthly, online periodical from May 2013, thus dear readers may refer to the journal website (www.aimjournal.ir) for free downloading of the published papers.

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Excerpts from Persian medical literature

Audit of Transfusion-related Practices and Equipment in 102 Hospitals

Blood banks are the link between blood centers and hospitals. A blood transfusion organization places emphasis on the application of standard operating procedures (SOPs), the use and calibration of blood bank equipment, and preventive measures for probable risks and mistakes. The current study has evaluated 102 blood banks according to practices and equipment, and then categorized the evaluated blood banks into three groups based on their scores. More...


About Us

A Monthly Peer-Reviewed Medical Journal Published by the Academy of Medical Sciences of the I.R. Iran; Indexed in PubMed/MEDLINE, ISI Web of Science, EMBASE, SCOPUS, CINHAL, PASCAL, CSA, SID, ISSN: Print 1029-2977, Online 1735-3947.The impact factor of Archives of Iranian Medicine according to Journal Citation Reports®(JCR®) 2012 is 1.222.

Selected Article
Therapeutic Effects, Tolerability and Safety of a Multi-strain Probiotic in Iranian Adults with Irritable Bowel Syndrome and Bloating 1

Authors' affiliation: ¹Digestive Diseases Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. ²Masoud clinic, Kargar Shomali Avenue ,Tehran, Iran .

•Corresponding author and reprints: HomayoonVahedi MD, Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. 14117-13135-North Kargar Ave., Shariati hospital, Tehran-Iran. Tel: +98-21-82414-82415000, Fax: +98-21-82415400, E-mail: vahedi@ams.ac.ir

Accepted for publication: 20 February 2014

 

Pubmedxml   Download PDF Fulltext
Authors: Elham Jafari1, *Homayoon Vahedi2, Shahin Merat3, Shabnam Momtahen4, Aina Riahi5,
 
Keywords: Adults, bloating, IBS, Iran, probiotic

BACKGROUND: Irritable bowel syndrome (IBS) is a common disorder in Iran with challenging treatment. Although trials have suggested that probiotics alleviate the complaints of patients with minimal side effects, they have not been investigated in Iranian adults.
METHODS: In a randomized double-blind study, 108 eligible IBS patients (Rome III Criteria) aged 20 – 70 years who referred consecutively to a clinical center in Tehran with abdominal bloating from 2010 to 2012 received a combination probiotics or placebo twice daily for 4 weeks. The objective was to evaluate the efficacy and safety of a multi-strain probiotics combination. One week prior to and throughout the treatment, the participants recorded their abdominal symptoms on a daily basis, using visual analogue scale and reported satisfactory relief of general symptoms at the end of each week. Adverse events were evaluated by self-reporting and physical examination. Continuous variables were analyzed by independent t-test and chi-square was used for binomials.
RESULTS: The baseline characteristics were balanced (60% female, mean age 36.7 ± 11.5). A total of 97 (51 intervention, 46 control) completed the treatment. Intention to treat analysis was done on 108 allocated subjects. 85% of the probiotic group reported satisfactory relief of general symptoms compared with 47% in the control group (P < 0.01). A reduction in abdominal bloating and pain with probiotic was superior to placebo [-13.0 vs. -3.7 (P < 0.01), -8.2 vs. -2.1 (P = 0.02), respectively]. No severe adverse drug reaction was seen in either group.
CONCLUSIONS:  A 4-week period of treatment with the combination probiotics twice daily was safe, well tolerated, and effective in our patients. Further investigation is recommended for other subgroups of IBS. Trial Registration: IRCT.ir IRCT2012071010230N1

 
ISSN:1029-2977       Article type:Original
  
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