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Arch Iran Med. 2018;21(9):399-405.
PMID: 30221530
  Abstract View: 571
  PDF Download: 430

Original Article

Tryptophan Degradation and Antioxidant Status in Patients With Thyroid Disorders 

Songül Ünüvar 1,2 * , Gözde Girgin 2, Tevfik Tolga Şahin 3,4, Bilge Kılıçarslan 2, Ferit Taneri 3, Osman Yüksel 3, Terken Baydar 2

1 İnönü University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Malatya, Turkey
2 Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ankara, Turkey
3 Gazi University, Faculty of Medicine, Deptarment of General Surgery, Ankara, Turkey
4 Health Sciences University, Adana Numune Training and Research Hospital, General Surgery, Adana, Turkey
*Corresponding Author: Songül Ünüvar, PhD; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, İnönü University, Malatya, Turkey. Tel: +90-422-341-0660, Fax: +90-422-341-1217, Email: Email: songul.unuvar@inonu.edu.tr

Abstract

Background: The aim of this study was to evaluate the degradation of tryptophan (Trp), neopterin production and antioxidant capacity in patients with benign and malignant thyroid disease.

Methods: For this reason, the levels of tryptophan, kynurenine (Kyn) and neopterin, and superoxide dismutase (SOD) and catalase (CAT) enzyme activities in 67 thyroid patients were evaluated in our study and the results were compared with 30 healthy controls.

Results: Tryptophan and kynurenine levels in thyroid patients decreased compared to the control group. Patients with thyroid disease had lower CAT activity than the control group. The neopterin and tryptophan levels in malignant and benign patients were also significantly different.

Conclusion: The results of the present study suggest that thyroid disorders may lead to changes in tryptophan degradation, neopterin production and CAT enzyme activities

Keywords: Antioxidant enzymes, Indoleamine 2,3-Dioxygenase activity, Kynurenine, Neopterin, Thyroid diseases, Tryptophan

Cite this article as: Ünüvar S, Girgin G, Şahin T, Kılıçarslan B, Taneri F, Yüksel O, Baydar T. Tryptophan degradation and antioxidant status in patients with thyroid disorders. Arch Iran Med. 2018;21(9):399–405.

 

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Submitted: 18 Jan 2018
Accepted: 02 Jul 2018
First published online: 01 Sep 2018
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