Arch Iran Med. 2011;14(3): 167-169.
PMID: 21529103
Scopus ID: 79961197263
  Abstract View: 582
  PDF Download: 328

Original Article

Treatment of Relapsed Acute Promyelocytic Leukemia by Arsenic Trioxide in Iran

Kamran Alimoghaddam * , Ardeshir Ghavamzadeh, Mohamad Jahani, Asadolah Mousavi, Masoud Iravani, Shahrbano Rostami, Hamidolah Ghaffari, Mehdi Jalili, Roholah Hosseini


BACKGROUND: Although standard first line treatment of acute promyelocytic leukemia is All trans retinoic acid (ATRA) and chemotherapy, some patients relapse and need a second line of treatment. Relapsed cases of promyelocytic leukemia can be salvaged with arsenic trioxide.


METHODS: Between May 1999 and Jan. 2010, we treated 31 relapsed cases of promyelocytic leukemia with arsenic trioxide. These cases relapsed after previous treatment with ATRA and chemotherapy. We applied arsenic trioxide as 0.15 mg/kg iv infusion until complete remission. After achieving complete remission patients received 2-4 consolidation therapy in the same schedule as remission induction.


RESULTS: The median age of patients was 27 years. Complete remission rate was 77.4%. We observed four mortalities during remission induction. With a median follow up of 32 months, ten more relapses occurred.  Two year disease-free survival and overall survival for the entire cohort was 54.6% and 81.1%, respectively.


CONCLUSION: Our result is the same as other studies. Thus, we suggest that arsenic trioxide can be used as salvage therapy in patients who relapsed. Despite a good complete remission rate, the relapse rate during the first two years of treatment is high and hematopoietic stem cell transplantation should be considered after achieving complete remission



First Name
Last Name
Email Address
Security code

Abstract View: 582

Your browser does not support the canvas element.

PDF Download: 328

Your browser does not support the canvas element.

ePublished: 01 May 2011
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)