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Arch Iran Med. 2012;15(1):0-0.
PMID: 22208441
Scopus id: 84855732712
  Abstract View: 520
  PDF Download: 353

Original Article

Five-Year Follow-up Of The Local Autologous Transplantation of CD133+ Enriched Bone Marrow Cells in Patients with Myocardial Infarction

Hossein Ahmadi, Maryam Moshkani Farahani, Azam Kouhkan, Kasra Moazzami, Roghayeh Fazeli, Hakimeh Sadeghian, Mehrnaz Namiri, Manouchehr Madani-Civi, Hossein Baharvand, Nasser Aghdami *

Abstract

BACKGROUND:The implantation of a CD133+ bone marrow cell population into an ischemic myocardium has emerged as a promising therapeutic modality for myocardial regeneration and restoration of ventricular contractility. While previous studies have documented the short-term safety and efficacy of CD133+ cell transplantation in patients with acute myocardial infarction, there are few reports of long-term follow-up results. Here, we present the results of long-term follow-up of our acute myocardial infarction patients who were treated with intramyocardial injection of CD133+ cells after coronary bypass graft.
METHODS: After five years, 13 patients in the cell transplantation group and 5 patients in the control group underwent safety and efficacy investigations by New York Heart Association classification and two-dimensional echocardiography (2D echo).
RESULTS:During the five-year study period, no major cardiac adverse events were reported among patients who received CD133+ stem cells. Regarding efficiency, we observed no statistically significant treatment effects for the echocardiographic parameters [left ventricular end-diastolic and end-systolic volumes, and resting ejection fraction] measured during the follow-up period. However, detailed analysis of regional wall motion revealed an improvement in the Wall Motion Score Index from baseline to the six month follow-up, which was maintained during the follow-up period.
CONCLUSION:Taken together, the long-term results of the present study indicate that transplantation of CD133+ is a safe and feasible procedure; however, we could not show any major benefits in our patients. Thus, this issue needs to be addressed by conducting other studies with more patients.

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First published online: 01 Jan 2012
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