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Arch Iran Med. 2012;15(5):303-305.
PMID: 22519380
Scopus id: 84875585241
  Abstract View: 413
  PDF Download: 288

Original Article

Severe Thrombocytopenia and Hemorrhagic Diathesis due to Brucellosis

Hasan Karsen * , Fazilet Duygu, Kubilay Yapıcı, Ali İrfan Baran, Huseyin Taskıran, İrfan Binici

Abstract

BACKGROUND: We aimed to examine cases of brucellosis that presented with severe thrombocytopenia and hemorrhagic diathesis.
METHODS: A total of 10 brucellosis cases with severe thrombocytopenia were included in this case-series study. Patients’ files were reviewed for their clinical and laboratory findings, as well as clinical outcomes and complications. Platelet counts of < 20000/mm³ were diagnosed as severe thrombocytopenia.
RESULTS: The lowest thrombocyte count was 3000/mm³ while the highest was 19000/mm³ (mean: 12000/mm³). Patients had the following symptoms: epistaxis (7 cases), petechia with epistaxis (4 cases), bleeding gums (3 cases), ecchymosis with epistaxis (2 cases), melena and renal failure (2 cases), and hematuria (1 case). Patients were given rifampicin and doxycycline along with supportive hematological therapy. All were treated successfully with no evidence of recurrence at follow-up visits.
CONCLUSION: Since brucellosis is endemic in developing countries, it must be considered in the differential diagnosis of cases that present with severe thrombocytopenia and hemorrhagic diathesis.

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First published online: 01 May 2012
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