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Arch Iran Med. 2013;16(2):0-0.
PMID: 23360625
Scopus id: 84874361987
  Abstract View: 435
  PDF Download: 326

Original Article

Outcomes of Liver Transplantation for Patients with Acute Liver Failure

Kamran Bagheri Lankarani, Kavus Eshraghian, Seyed Ali Malek-Hosseini, Parisa Janghorban, Bita Geramizadeh, Ahad Eshraghian *

Abstract

BACKGROUND: Liver transplantation is a treatment for patients who have acute liver failure (ALF). This study aims to evaluate the outcomes following liver transplantation in patients with ALF and compare them with cirrhotic patients who underwent liver transplantation.

METHODSMethods: This retrospective cross-sectional study was conducted at Shiraz Organ Transplant Center between June 2004 and March 2011 to evaluate the clinical presentation and underlying etiology of patients with ALF and their outcomes following liver transplantation.
RESULTS: Out of 750 patients who underwent liver transplants, 12 (8 males and 4 females) had a diagnosis of ALF. The cirrhotic group (control) consisted of 20 transplanted patients. ALF patients were younger with a mean age of 18.7 ± 12.9 years compared to 37.4 ± 13.6 years in the cirrhotic group (P = 0.001). In the ALF group, 5 (41.66%) underwent partial living related liver transplantation compared to 1 (5%) in the cirrhotic group (P = 0.018). There were significantly more early post-transplant complications observed among patients with ALF compared to the cirrhotic group (P = 0.002).
CONCLUSION: Liver transplantation is safe, effective and should be considered in patients diagnosed with ALF.
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First published online: 01 Feb 2013
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