Arch Iran Med. 2013;16(5): 0-0.
PMID: 23641737
Scopus ID: 84877798943
  Abstract View: 874
  PDF Download: 475

Original Article

Major Adverse Events, Six Months after Endovascular Revascularization for Critical Limb Ischemia in Diabetic Patients

Seyed Ebrahim Kassaian, Mohammadreza Mohajeri-Tehrani * , Alireza Dehghan-Nayyeri, Sepideh Saroukhani, Zohre Annabestani, Mohammad Alidoosti, Shapour Shirani, Abolfazl Shojaei-Fard, Behnam Molavi, Hamid Reza Pourhoseini, Mojtaba Salarifar, Maryam Aboee-Rad, Mina Pashang, Bagher Ardeshir Larijani


 BACKGROUND: This prospective study aimed to evaluate the detailed outcomes of diabetic patients with critical limb ischemia, six months after percutaneous transluminal angioplasty and appropriate multidisciplinary wound care. 

METHODS: Totally, 45 consecutive patients (50 limbs) were enrolled and then divided into two groups according to the healing of ulcers. The endpoints were ulcer healing and major adverse events including amputation, mortality, and cardiac or cerebral morbidities, during a six- month follow-up period. 
RESULTS: During six months follow-up, major amputation was performed for four of 50 limbs (8.0%). A total of nine (20%) patients died and the leading cause was cardiac death (13.3 %). Also, stroke and non-fatal myocardial infarction occurred in three (6.7 %) and one (2.2 %) of the patients, respectively. Among the 29 (59.2 %) healed wounds, 22 (44.9 %) were completely closed. The patients with nonhealing wounds had a higher rate of dialysis (40% vs. 0 %, P-value < 0.001) and more ulcers with stage of D3 according to the Texas Wound Classification (60% vs. 31 %, P-value = 0.016). Other demographic, clinical, ulcer characteristics and procedural characteristics such as number and level of the treated lesions did not differ significantly between the two groups. 
CONCLUSION: Based on our findings, it seems that along with current usual therapeutic routines which focus on wound healing and limb salvage, more attention should be paid to simultaneous diagnostic assessments and treatment of cardiovascular disease in this group of patients during short-term follow- up. 
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