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Arch Iran Med. 2014;17(4): 0-0.
PMID: 24724602
Scopus ID: 84899655223
  Abstract View: 724
  PDF Download: 476

Original Article

Detection and Biological Characteristic of FLT3 Gene Mutations in Children with Acute Leukemia

Nahid Nasiri, Maryam Shaikhy, Farhad Zaker * , Soudabeh Hosseini, S. A. Moosavi, Abdol Jalal Marjani

Abstract

INTRODUCTION: FLT3 ITD and D835 mutations occur in high frequency in AML and to a lower rate in ALL patients with poor prognosis.
METHODS: ITD and D835 mutations were studied in 100 diagnosed acute leukemia patients including 27 AML and 73 ALL with various FAB classifications by PCR and PCR-RFLP, respectively. Subsequently, PCR products of positive samples were confirmed by sequencing analyses.
RESULTS: ITD mutations occurred in 10% of all pediatric acute leukemia, including AML and ALL. 25.9% of AML patients harbor a mutation in the ITD in various subtypes. The frequency of ITD mutations was 4% in ALL. Various insertions of nucleotides in ITD were observed, similar to those described in the literature previously.
CONCLUSION: These preliminary data suggest that flt3-ITD mutations may play an important role in leukemogenesis in a proportion of children, particularly in the case of AML.

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ePublished: 01 Apr 2014
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