Logo-aim
Arch Iran Med. 2015;18(10): 0-0.
PMID: 26443251
Scopus ID: 84943559388
  Abstract View: 472
  PDF Download: 398

Original Article

Genetic Investigation of an Iranian Supercentenarian by Whole Exome Sequencing

Tara Akhtarkhavari, Mohammad Taghi Joghataei, Zohreh Fattahi, Mohammad Reza Akbari, Farzaneh Larti, Hossein Najmabadi, Kimia Kahrizi *

Abstract

 BACKGROUND: The genetic basis of longevity is an important field of study because the majority of supercentenarian cases experience healthy aging and may only show age-related diseases in their last few years of life. It is clear that genetic factors play an important role in survival beyond 90 years of age, but the exact relationship of genetic variants to this phenomenon remains unknown.

OBJECTIVE: The aim of this project was to investigate different hypotheses that describe the relationship between genetic variants and human longevity in a living Iranian man by Whole Exome Sequencing.
METHODS: Initially, we conducted high quality DNA extraction on a peripheral blood sample. Then, whole exome sequencing was performed on the DNA and different bioinformatic software packages and databases were used to analyze the data. Tertiary analysis was performed on four genetic hypotheses for longevity.
RESULTS: Analysis showed that among 27 metabolic variants which are related to longevity, 18 variants encompassed the exceptional longevity allele. In comparison with the NHGRI GWAS catalog, the case had 58 trait-associated variants of which 11 were homozygous for the risk allele. We also discovered 25 novel variants within candidate genes for aging and longevity and we detected seven longevity-associated variants in the sample.
CONCLUSION: This study was performed on just one sample and so the results cannot be interpreted as a generalized principle for other elderly societies, but this is the first step towards investigation of the genetic basis of longevity in Iran and provides an insight for further studies in the field of longevity.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 472

Your browser does not support the canvas element.


PDF Download: 398

Your browser does not support the canvas element.

ePublished: 01 Oct 2015
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)