Arch Iran Med. 2016;19(4): 297-299.
PMID: 27041528
Scopus ID: 84961916147
  Abstract View: 649
  PDF Download: 563

Case Report

Two Cases of MUM-1 and bcl-2 Positive Primary Diffuse Large B Cell Non-Hodgkin’s Lymphoma of the Colon Successfully Treated with Surgery and Immunohemotherapy

Vladimir Jurisić, Mirjana Plećić, Natasa Colović, Vesna Čemerikić-Martinović, Marko Janković, Milica Čolović


Primary diffuse large B cell lymphoma (DLBCL) presents as a nodal and extranodal disease. The most common extranodal site is the gastrointestinal tract (GI), with the stomach most frequently involved, followed by the small bowel. Primary DLBCL of the large bowel accounts for 0.2%–1.2% of all colonic tumors. We present two patients who underwent radical resections of right colonic tumors. They were diagnosed with primary colonic DLBCL following histological and immunohistochemical testing of the excised tissues, and were determined as being in stage IIE of the disease. The tumors expressed CD20 markers. Both received multi-agent chemotherapy with combined immunotherapy and remain in complete remission at 4 and 5 years.

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ePublished: 01 Apr 2016
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