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Arch Iran Med March. 2020;23(3): 169-174.
  Abstract View: 243
  PDF Download: 313

Original Article

Impact of Age on the Prognosis of Papillary Thyroid Carcinoma

Yue Sun 1 ORCID logo, Weiran Dai 2, Yuzhen Liang 3, Ning Xia 1 *

1 Department of Endocrinology, The first affiliated hospital of Guangxi Medical University, Nanning, Guangxi, China
2 Guangxi Medical University, Nanning, Guangxi, China
3 Department of Endocrinology, The second affiliated hospital of Guangxi Medical University, Nanning, Guangxi, China

Abstract

Background: Papillary thyroid carcinoma (PTC) is a common subtype of thyroid carcinoma with a rising incidence rate. The purpose of this study was to provide a better understanding of age and PTC using the Surveillance, Epidemiology, and End Results (SEER) Program.

Methods: The study derived patients’ information from the SEER Program (2010–2015). Chi-square or Fisher exact tests, and Kaplan–Meier method were used to analyze survival. Prognostic factors associated with survival were analyzed by Cox multivariate regression.

Results: A total of 1738 records were included from SEER, with 1079 PTC in the age group <55 years, and 659 PTC in the age group ≥55 years. The 5-year survival rate was 94% and the overall survival (OS) curve in different age groups indicated that patients younger than 55yr have a longer survival time (P<0.05). In multivariate Cox regression, age, M stage and surgery treatment were independent risk factors (P<0.05). Regarding PTC-specific survival, age and surgery treatment were the two main independent prognostic factors in multivariate regression. However, AJCC and M stage were not in the disease specific survival.

Conclusion: Age is a prognostic factor in OS and PCT specific survival. AJCC I stage and surgery treatment are also significant in predicting prognosis.

Keywords: Papillary thyroid cancer, Prognosis, SEER Program
Cite this article as: Sun Y, Dai W, Liang Y, Xia N. Impact of age on the prognosis of papillary thyroid carcinoma. Arch Iran Med. 2020;23(3):169–174.
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Abstract View: 243

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Submitted: 06 Aug 2019
Accepted: 27 Nov 2019
ePublished: 01 Mar 2020
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