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Arch Iran Med. 2019;22(4):198-203.
PMID: 31126178
  Abstract View: 191
  PDF Download: 253

Original Article

Mean Platelet Volume and Major Adverse Cardiac Events following Percutaneous Coronary Intervention

Younes Nozari 1, Maziar Parsa 1, Arash Jalali 1, Hamid Ariannejad 1, Akbar Shafiee 1 *

1 Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Akbar Shafiee MD MSc, Department of Cardiovascular Research, Tehran Heart Center, North Kargar St., 1411713138, Tehran, Iran. Tel: +98 21 88029257, Fax: +98 21 88029256. Email: Email: Dr_shafiee@alborzi.com

Abstract

Background: Mean platelet volume (MPV) has been introduced as a simple and accurate method for assessing platelet function, which can be used as a prognostic marker for cardiovascular events. We investigated whether pre-procedural MPV could predict major adverse cardiac events (MACE) in candidates for elective percutaneous coronary intervention (PCI).

Methods: In this large retrospective cohort, we reviewed the clinical and follow-up data of 4199 candidates (mean age = 59.9 ± 10.3 years; female patients = 1440 [34.3%]) for elective PCI due to unstable angina (UA) or non-ST segment elevation myocardial infarction (NSTEMI). The primary endpoint of the study was the incidence of MACE defined as in-hospital mortality, cardiac death, nonfatal MI, target lesion revascularization (TLR) or target vessel revascularization (TVR). Based on the MPV level tertiles, patients were categorized into three groups for further comparison.

Results: Higher MPV was significantly associated with older age (P<0.001), hypertension (P<0.001), diabetes mellitus (P=0.003), history of previous CABG (P<0.001) and lower levels of serum triglyceride (P<0.001). The frequency of 1-year MACE was 176 (4.1%) with no significant difference between the MPV tertile groups. The highest MPV tertile could significantly predict MACE in the univariable model (hazard ratio = 1.51, 95% confidence interval: 1.05–2.17; P=0.026). In the adjusted model, the highest MPV tertile was a borderline predictor for MACE (hazard ratio = 1.62, 95% CI: 0.98–2.68; P=0.057).

Conclusion: High MPV was associated with cardiovascular risk factors and older age while high MPV was a borderline independent predictor for 1-year MACE in the candidates for elective PCI

Keywords: Coronary artery disease, Mean platelet volume, Major adverse cardiac events, Non-ST elevation myocardial infarction, Percutaneous coronary intervention, Platelet count
Cite this article as: Nozari Y, Parsa M, Jalali A, Ariannejad H, Shafiee A. Mean platelet volume and major adverse cardiac events following percutaneous coronary intervention. Arch Iran Med. 2019;22(4):198–203.
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Submitted: 26 Nov 2018
Accepted: 13 Feb 2019
First published online: 01 Apr 2019
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