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Arch Iran Med. 2021;24(8): 615-621.
doi: 10.34172/aim.2021.87
  Abstract View: 270
  PDF Download: 255

Original Article

Long-term Results of Low Grade Appendiceal Mucinous Neoplasm (LAMN): A Retrospective Analysis of 24 Patients

Mustafa Gok 1 ORCID logo, Ugur Topal 1,2* ORCID logo, Muhammet Akyüz 1 ORCID logo, Abdullah Bahadır Öz 1 ORCID logo, Erdogan Sozuer 1,2 ORCID logo, Kemal Deniz 3 ORCID logo

1 Department of General Surgery, Erciyes University Medical Faculty, Melikgazi, Kayseri, Turkey
2 Department of Surgical Oncology, Erciyes University Medical Faculty, Melikgazi, Kayseri, Turkey
3 Department of Pathology, Erciyes University Medical Faculty, Melikgazi, Kayseri, Turkey
*Corresponding Author: Uğur Topal, MD; Department of General Surgery, Erciyes University Faculty of Medicine, 38030 Melilgazi/Kayseri, TURKEY. Tel: +90 530 1139112; Fax: +90 352 437 52 73; Email: sutopal2005@hotmail.com

Abstract

Background: Appendix tumors are rare tumors found in the gastrointestinal tract, observed at a rate of about 0.2%–0.3%. Our aim in this study was to present the clinicopathological classification, treatment and long-term prognosis of patients with low grade appendiceal mucinous neoplasm (LAMN).

Methods: Patients who underwent surgery in the Erciyes University Department of (Kayseri, Turkey), Department of General Surgery between December 2010 and December 2018, and who had LAMN as a result of pathology were included in our study. Demographic data, clinical and pathological features of the disease, their treatment and follow-up results after treatment were reviewed retrospectively.

Results: We included 24 patients in the study. Of these patients, 10 (41.6%) were male. The mean age distribution was 56.4 ± 20.3 (21–91) years. Appendectomy was performed in 14 patients, and additional organ resections were performed in 8 patients. The most common symptom at the time of presentation was abdominal pain (79.1%; 95% CI, 58.3–91.7). The most common preliminary diagnosis in the preoperative period was acute appendicitis (50%; 95% CI, 29.2–70.8). Mean postoperative hospitalization time was 7.4 ± 7.96 (2–31) days. On pathological examination, appendectomy resection margins were positive in two patients. The mean (median) postoperative follow-up was 31.25 ± 23.9 (27) (1–90) months. One-year survival was 91.6%, and 5-year survival was 83.3%. Recurrence was detected in three patients during the follow-up period.

Conclusion: If appendix mucinous neoplasia (AMN) is suspected in patients undergoing surgery with an initial diagnosis of acute or plastron appendicitis, care should be taken to remove the lesion without perforation. Pseudomyxoma peritonei, which may develop as a result of perforation, is associated with recurrence and decreased survival.


Keywords: Appendix, Low grade mucinous neoplasm, Mucinous tumor, Pseudomyxoma peritonei
Cite this article as: Gok M, Topal U, Akyüz M, Öz AB, Sozuer E, Deniz K. Long-term results of low grade appendiceal mucinous neoplasm (LAMN): a retrospective analysis of 24 patients. Arch Iran Med. 2021;24(8):615-621. doi: 10.34172/aim.2021.87
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Abstract View: 271

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PDF Download: 255

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Submitted: 18 Mar 2020
Accepted: 27 Sep 2020
ePublished: 01 Aug 2021
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