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Arch Iran Med. 2018;21(1): 29-40.
PMID: 29664668
  Abstract View: 868
  PDF Download: 652

Review

Intellectual Disability and Ataxia: Genetic Collisions

Somayeh Kazeminasab 1, Hossein Najmabadi 1, Kimia Kahrizi 1 *

1 Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
Corresponding Author: Kimia Kahrizi, Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran kahrizi@yahoo.com

Abstract

Intellectual disability (ID) is a common and highly heterogeneous neurodevelopmental disorder. The prevalence of ID is around 1%–3% in the general population. ID is associated with a wide range of additional neurological disabilities and the results of various studies have disclosed the co-morbidity of ID and ataxia. The aim of this review is elucidation of the common molecular and cellular pathways in the etiology of ID and ataxia. Categorization of these genes with various cellular functions indicates several genetic collisions in the co-occurrence of ID and ataxia. 
Keywords: Ataxia, Ciliogenesis, Ion channels, Intellectual disability, Mitochondria
Cite this article as: Kazeminasab S, Najmabadi H, Kahrizi K. Intellectual disability and ataxia: genetic collisions. Arch Iran Med. 2018;21(1):29–40.
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Abstract View: 868

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Submitted: 03 Jun 2017
Accepted: 15 Nov 2017
ePublished: 01 Jan 2018
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