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Arch Iran Med. 2021;24(8): 599-606.
doi: 10.34172/aim.2021.85
  Abstract View: 306
  PDF Download: 263

Original Article

Assessment of Bone Mineral Density in Patients Undergoing Hemodialysis; An Iranian Population-Based Study

Saeid Amirkhanlou 1 ORCID logo, Gholamreza Roshandel 2 ORCID logo, Mehrdad Aghaei 3, Hossein Mohebi 4, Sahab-Sadat Tabatabei 5, Shiva Momen 6, Peyman Zia 7, Mehdi Aarabi 8,9, Farzad Amouzadeh 10, Seyyed-Mohsen Hosseininejad 11,9* ORCID logo

1 Department of Nephrology, Clinical Research Development Unit, Sayad Shirazi Hospital, Golestan University of Medical Sciences, Gorgan, Iran
2 Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
3 Joint, Bone, Connective tissue, Rheumatology Research Center (JBCRC), Golestan University of Medical Sciences, Gorgan, Iran
4 Department of Orthopedic Surgery, Kermanshah University of Medical Sciences, Kermanshah, Iran
5 Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Student Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
7 Department of Orthopedic Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8 Department of Orthopedic Surgery, Toronto East General Hospital, University Health Network, Toronto, Ontario, Canada
9 Joint, Bone, Connective tissue, Rheumatology Research Center (JBCRC), Golestan University of Medical Sciences, Gorgan, Iran
10 Emem-Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
11 Bone Joint and Related Tissues Research Center, Akhtar Orthopedic Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Corresponding Author: Seyyed-Mohsen Hosseininejad, MD, Bone Joint and Related Tissues Research Center, Akhtar Orthopedic Hospital, Shahid Beheshti University of Medical Sciences, Elahiyeh, Tehran, Iran. Email: Hosseininejad.s.mohsen@gmail.com

Abstract

Background: End-stage renal disease (ESRD) is a condition in which bone turnover and metabolism is impaired; thus, osteoporosis and low bone density are subsequently inevitable. We aimed to determine bone mineral density (BMD) and biochemical markers, and associated factors in hemodialysis (HD) patients.

Methods: Patients aged 30-70 years undergoing HD between 2015 to 2019 were enrolled in this cross-sectional study. BMD measured by dual energy x-ray absorptiometry (DEXA) and biochemical laboratory tests were assessed in 200 patients undergoing HD. Statistical analysis was based on t test, Pearson, regression and Mann-Whitney tests using SPSS 16.

Results: Two hundred patients were investigated. Sixty percent of the patients were female. Mean ± SD of participants’ age was 58.6 (±11.63) years and mean ± SD for duration of HD was 45.69 (± 43.76) months. Osteoporosis was found in 48% (n=96) and low bone density in 36% (n=76) of our patients. General osteoporosis was more frequent in those undergoing HD for more than 3 years, although not significantly (P=0.093, odds ratio [OR]=0.37). However, regional osteoporosis in hip and femoral neck, but not spine vertebrae, were significantly higher after three years of HD (P=0.036, OR=0.27; P=0.042, OR=0.27; and P=0.344, OR=0.56, respectively). Increased body mass index (BMI) correlated negatively with osteoporosis (P=0.050).

Conclusion: With increasing age and duration of HD, BMD decreases. Higher BMI was associated with higher bone mass density. Bone density assessment seems to be necessary in patients undergoing HD.


Keywords: Biomarkers, Bone mineral density, Osteoporosis, Renal dialysis, Risk factors
Cite this article as: Amirkhanlou S, Roshandel G, Aghaei M, Mohebi H, Tabatabei SS, Momen S, et al. Assessment of bone mineral density in patients undergoing hemodialysis; An Iranian population-based study. Arch Iran Med. 2021;24(8):599-606. doi: 10.34172/aim.2021.85
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Submitted: 30 Aug 2020
Accepted: 06 Dec 2020
ePublished: 01 Aug 2021
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