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Arch Iran Med. 2021;24(8): 622-628.
doi: 10.34172/aim.2021.88
  Abstract View: 260
  PDF Download: 215

Original Article

Association between Angiopoietin-2 Gene Polymorphisms and Susceptibility to Coronary Artery Disease

Luhang Lan 1 ORCID logo, Le Kang 2, Liang Lu 1, Xuan Ge 1, Hongping Si 1, Jiren Peng 1, Maofeng Wang 2, Weimin Li 1* ORCID logo, Chen-Ming Su 3*

1 Department of Cardiology, Affiliated Dongyang Hospital of Wenzhou Medical University, Wuningxi Road 60, Dongyang, Zhejiang, China
2 Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Wuningxi Road 60, Dongyang, Zhejiang, China
3 Department of Sports Medicine, China Medical University, Taichung, Taiwan
Chen-Ming Su, PhD, Department of Sports Medicine, China Medical University, No.91 Hsueh-Shih Road, Taichung, Taiwan. Tel: +886-4-22053366; Email: proof814@gmail.com

Abstract

Background: Angiopoietin-2 (Angpt2) is associated with the progression of coronary artery disease (CAD). This research aimed to investigate the possible association between single nucleotide polymorphisms (SNPs) of ANGPT2 and CAD.

Methods: This research was performed in a hospital from the eastern region of China. From February 2019 to June 2019, 222 patients with CAD were newly diagnosed and 403 healthy controls were confirmed by physical examinations. The distribution frequency of five SNPs of the ANGPT2 (rs11137037, rs2442598, rs12674822, rs1823375, and rs734701) in all participants was analyzed by real-time polymerase chain reaction (PCR) with SNP locus-specific probes.

Results: Our data showed that the participants with the TT genotype of rs2442598 were at reduced risk of CAD compared with wild-types (adjusted odds ratio [AOR] = 0.511, 95% CI: 0.283–0.923). The participants with the AC and AC+CC genotypes of rs11137037 were at greater risk of CAD compared to wild-types (AOR = 1.754, 95% CI: 1.140-2.699; AOR = 1.731, 95% CI: 1.165–2.573, respectively). In addition, carriers of the GG+TT genotypes of rs12674822, showed more significant high-density lipoprotein than those of GG genotype, in addition, carriers of the GG+TT genotypes of rs12674822, showed more significant high-density lipoprotein than those of GG genotype (P=0.037).

Conclusion: These findings, as well as analysis of the haplotype, clearly indicate that ANGPT2 SNPs were highly correlated with susceptibility to CAD among the Han Chinese population.


Keywords: Angiopoietin-2, Coronary artery disease, Single nucleotide polymorphism
Cite this article as: Lan L, Kang L, Lu L, Ge X, Si H, Peng J, et al. Association between angiopoietin-2 gene polymorphisms and susceptibility to coronary artery disease. Arch Iran Med. 2021;24(8):622-628. doi: 10.34172/aim.2021.88
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Submitted: 07 Sep 2020
Accepted: 30 Dec 2020
ePublished: 01 Aug 2021
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