Arch Iran Med. 2019;22(5): 255-261.
PMID: 31256599
Scopus ID: 85068725415
  Abstract View: 1663
  PDF Download: 1092

Original Article

The Effect of Conjugated Linoleic Acid Supplementation on Body Composition, Serum Insulin and Leptin in Obese Adults

Fatemeh Esmaeili Shahmirzadi 1, Saeid Ghavamzadeh 1*, Tayebeh Zamani 1

1 Food and Beverage safety research center, Department of Human Nutrition, Medicine Faculty, Urmia University of Medical Sciences, Urmia, Iran


Background: Studies have reported contradictory findings regarding the effect of a mixture of 2 conjugated linoleic acid (CLA) isomers on body weight and some serum indices. This study aims to investigate the effect of daily supplementation of these 2 isomers on body composition and serum leptin and insulin levels in obese adults.

Methods: This randomized, double-blind clinical trial was performed on 54 adults with class I obesity. The subjects were randomly assigned into 2 groups of 27 and were followed for 3 months so that a total of 3000 mg of CLA supplement and placebo were administered in 3 daily doses in the intervention and control groups, respectively. Body composition indices as well as fasting serum levels of insulin and leptin were also measured. The paired t-test was used for evaluating within-group effects from baseline. The independent t-test was used to compare between-group differences for variables with normal distribution.

Results: Although body weight and body mass index (BMI) were not significantly decreased during intervention in groups, but the body fat mass (BFM) (P=0.034), body fat percentage (P=0.022) and trunk fat (P=0.027) decreased significantly during intervention with CLA. The fasting plasma sugar (P=0.042) and Homeostatic model assessment for insulin resistance (HOMA/IR) (P=0.044) in the intervention group declined during 12 weeks of intervention. Serum leptin was associated with a significant decrease during the intervention period (P=0.039).

Conclusion: CLA supplementation could reduce body fat and serum leptin. Hence, it could be taken into account as a factor for weight loss but not to control or prevent diabetes.

Keywords: Body composition, Conjugated linoleic acid, Insulin, Leptin
Cite this article as: Esmaeili Shahmirzadi F, Ghavamzadeh S, Zamani T. The effect of conjugated linoleic acid supplementation on body composition, serum insulin and leptin in obese adults. Arch Iran Med. 2019;22(5):255–261.
First Name
Last Name
Email Address
Security code

Abstract View: 1664

Your browser does not support the canvas element.

PDF Download: 1092

Your browser does not support the canvas element.

Submitted: 15 Apr 2018
Accepted: 23 Dec 2018
ePublished: 01 May 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)