Arch Iran Med. 2019;22(1):53-56.
PMID: 30821162
Scopus id: 85062433558
  Abstract View: 125
  PDF Download: 163

Case Report

Electrocardiographic Changes Following Acute Hydralazine Overdose

Maryam Vahabzadeh 1, Ali Eshraghi 2, Mina Akbari-Rad 3 * , Abdollah Firoozi 4, Alireza Esmaeili 5, Yaghoub Ahrari 6

1 Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Cardiology Department of Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Internal Medicine, Gheam Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4 Mashhad University of Medical Sciences, Mashhad, Iran
5 Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
6 Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Hydralazine is an FDA-approved antihypertensive agent which has been utilized for years either alone or in combination with other medications especially the beta-blockers. Hydralazine works as a direct-acting vasodilator, thereby exerting a decrease in vascular resistance and increase in intravascular volume. When overdosed, hydralazine applies its toxic effects by extending its pharmacological action, which produces hypotension, syncope, tachycardia, and nausea. However, studies and case reports of acute hydralazine toxicity and its effects on electrocardiographic changes are rare, and most of the medical literature have only highlighted its immunological side effects. In this report, we are presenting a case of acute hydralazine overdose in a young woman who ended up in CCU due to remarkably abnormal electrocardiogram and unstable hemodynamics followed by myocardial infarction.
Cite this article as: Vahabzadeh M, Eshraghi A, Akbari-Rad M, Firoozi A, Esmaeili A, Ahrari Y. Electrocardiographic changes following acute hydralazine overdose. Arch Iran Med. 2019;22(1):53–56.
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Submitted: 25 May 2018
Accepted: 13 Oct 2018
First published online: 01 Jan 2019
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