Arch Iran Med. 2018;21(7): 275-282.
PMID: 30041524
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Original Article

Liver Transplantation Status in Iran: A Multi-center Report on the Main Transplant Indicators and Survival Rates

S. Ali Malek-Hosseini 1, Ali Jafarian 2, Saman Nikeghbalian 1, Hossein Poustchi 3, Kamran B. Lankarani 1, Mohsen Nasiri Toosi 2, Heshmatollah Salahi 1, Mohsen Dehghani 1, Ahad Eshraghian 1, Maryam Sharafkhah 3, Sareh Eghtesad 3, Nazgol Motamed-Gorji 3, Kourosh Kazemi 1, Javad Salimi 2, Majid Moini 2, Alireza Shamsaeefar 1, Maryam Moini 1, Masoud Dehghani 4, Mohammad B. Khosravi 1, Atabak Najafi 2, Hossein Sattari 4, Bita Geramizadeh 1, Mohammad Shafiee 4, Mohammad N. Toutouni 5, Behnam Sanei 6, Seyed Mohammadreza Nejatollahi 7, Alireza Taghavi 1, Ali Bahador 1, Mohsen Aliakbarian 5, Bijan Eghtesad 8 * , Reza Malekzadeh 3

1 Shiraz Transplant Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
2 Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
3 3 Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4 Transplant Program, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran
5 Transplant Program, Department of Surgery, Mashhad University of Medical Sciences, Mashhad, Iran
6 Liver Transplant and Hepatobiliary and Pancreatic Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
7 The Division of Hepatobiliary and Organ Transplantation, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8 Hepatobiliary/Liver Transplant Surgery, Cleveland Clinic, Cleveland, Ohio, USA
*Corresponding Author: Bijan Eghtesad, MD, HPB/Liver Transplant Surgery, Cleveland Clinic, Desk A-100, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. Phone: 216-444-989, Fax: 216-444-9375, eghtesb@ccf.org


Background: Iran’s experience with liver transplantation (LT) began more than two decades ago. The purpose of this article is to present the status of LT in Iran, review specific characteristics of the programs, their outcomes, and their growth to become one of the largest LT programs in the world.

Methods: A questionnaire, asking for data on the number of transplants performed and specifics of the recipients and type of donors with focus on indications and outcomes was sent to LT programs.

Results: During a period of 23 years, 4,485 LTs were performed at 6 centers in the country. Of these, 4106 were from deceased donors and 379 were from living donors. There were 3553 adults and 932 pediatric recipients. Hepatitis B and biliary atresia were the most common etiologies in adult and pediatric patients, respectively. Overall survival rates at 1, 5, and 10 years were 85%, 77%, and 71% for adults and 76%, 67% and 56% for pediatric patients, respectively.

Conclusion: Approval of the brain death law in Iran and coordinated efforts by the transplant centers to build comprehensive LT programs has resulted in the ability to procure more than 700 deceased donors per year with acceptable long-term survival. 

Keywords: Deceased organ donation in Iran, Liver transplantation, Organ transplantation in Iran
Cite this article as: Malek-Hosseini SA, Jafarian A, Nikeghbalian S, Poustchi H, Lankarani KB, Nasiri Toosi M, et al. Liver transplantation status in Iran: a multi-center report on the main transplant indicators and survival rates. Arch Iran Med. 2018;21(7):275–282.
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Submitted: 29 Apr 2017
Accepted: 17 May 2018
ePublished: 01 Jun 2018
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