Arch Iran Med. 2018;21(12):611-612.
PMID: 30634861
Scopus id: 85059917618
  Abstract View: 169
  PDF Download: 183

Photoclinic

Extramedullary Manifestation of Multiple Myeloma in the Oral Cavity

Cristiano de Assis Pereira Hansen 1 * , Jayr Schmidt Filho 2, Marina de Mattos Nascimento 2, Fábio Abreu Alves 3, Tatiane Neotti 4, Felipe D´Almeida Costa 5

1 Former Medical Resident in Clinical Oncology, A.C.Camargo Cancer Center, São Paulo, Brazil
2 Hematologist, A.C.Camargo Cancer Center, São Paulo, Brazil
3 Chief of Dental Surgery Department, A.C.Camargo Cancer Center, São Paulo, Brazil
4 Former Medical Resident in Pathology, A.C.Camargo Cancer Center, São Paulo, Brazil
5 Pathologist, A.C.Camargo Cancer Center, São Paulo, Brazil

Abstract

Background: Extramedullary plasmacytomas occurs in about 20% of multiple myeloma (MM) recurrences. Extramedullary disease seems to respond poorly to thalidomide and has adverse prognostic implication. When disease recurs in the oral cavity with soft tissue infiltration, some authors defend upfront surgical excision prior to radiotherapy with the aim of achieving better local control. We describe herein such an atypical case of recurrence from MM, with complete local response after 2 cycles of chemotherapy. Unfortunately, disease progressed later on, and the patient died after 9 months post-recurrence. This emphasizes the prognostic impact of extramedullary disease manifestation in MM.
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Submitted: 06 Aug 2018
Accepted: 17 Sep 2018
First published online: 01 Jan 2019
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