Arch Iran Med. 2019;22(9): 527-530.
PMID: 31679375
  Abstract View: 476
  PDF Download: 288

Case Report

Pure Androgen-Secreting Adrenocortical Carcinoma Presenting with Hypoglycemia

Fariba Karimi 1 * ORCID logo, Amirreza Dehghanian 2, Mohammadjavad Fallahi 3, Behnam Dalfardi 3

1 Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2 Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Most patients present with steroid hormone excess or abdominal mass effect. Pure androgen-secreting ACCs are rare, while hypoglycemia is an unusual presentation of this malignancy. We present a 26-year-old woman with hypoglycemia and history of adrenalectomy due to a large adrenal mass which was diagnosed as nonfunctional adrenal adenoma. She was admitted in our hospital 10 days after her fetal loss with repeated episodes of severe hypoglycemia. She had a high serum dehydroepiandrosterone sulfate (DHEA-S) and her hypoglycemia was associated with low insulin and C-peptide levels. Imaging revealed liver metastasis and immunohistochemical studies of the biopsied lesions confirmed the diagnosis of ACC.
Keywords: Adrenocortical carcinoma, C-peptide, DHEA-S, Hypoglycemia, Insulin
Cite this article as: Karimi F, Dehghanian A, Fallahi M, Dalfardi B. Pure androgen-secreting adrenocortical carcinoma presenting with hypoglycemia. Arch Iran Med. 2019;22(9):527–530.
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Abstract View: 476

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Submitted: 23 Dec 2018
Accepted: 04 Feb 2019
ePublished: 01 Sep 2019
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