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Arch Iran Med. 2020;23(2): 99-103.
PMID: 32061072
Scopus ID: 85079361428
  Abstract View: 341
  PDF Download: 292

Original Article

Tetanus Immunoglobulin G Assessment in Adults Trauma Patients

Selçuk Nazik 1* ORCID logo, Filiz Orak 2, Hakan Hakkoymaz 3, Ahmet Rıza ŞAHİN 1

1 Kahramanmaraş Sütçü İmam University, Department of Infectious Disease and Clinical Microbiology, Kahramanmaraş, 46100, Turkey
2 Kahramanmaraş Sütçü İmam University, Department of Medical Microbiology, Kahramanmaraş, 46100, Turkey
3 Kahramanmaraş Sütçü İmam University, Department of Emergency, Kahramanmaraş, 46100, Turkey

Abstract

Background: Clostridium tetani is an anaerobic, gram-positive bacillus that causes tetanus infection. It usually enters the body through injury with contaminated objects. Tetanus differs from other diseases that can be prevented by vaccination in that it is not contagious and does not spread from person to person. The aim of this study is to evaluate the levels of Tetanus IgG in trauma patients admitted to the emergency department (ED).

Methods: The study was planned as cross-sectional, prospective, and single-center. The study was conducted from January to July 2018 in the Kahramanmaraş Sütçü İmam University Hospital. Totally, 178 patients aged ≥18 years were included. For measurement of the level of Tetanus IgG, Clostridium tetani toxin 5S IgG kit (NovaLisa, NOVATEC) was used to quantitatively detect IgG type antibodies by micro-ELISA method in accordance with the manufacturer’s recommendation.

Results: In total, 143 cases were male and 35 were female. The mean age of the cases was 40 ± 16 years. Tetanus IgG levels were found to be 0.29 ± 0.6 IU/mL in cases from rural areas and 2.14 ± 1.64 IU/mL in cases from urban areas (P < 0.001). There was a negative correlation between age and Tetanus IgG level (r: (-) 0.479; P < 0.001). The protective level of Tetanus IgG was observed to be even lower, especially in patients aged ≥40 years (n = 43, 78.9%).

Conclusion: Measurements of Tetanus IgG levels should be performed as far as possible in the ED. In this way, unnecessary vaccination can be avoided.

Keywords: Emergency department, Tetanus Ig G, Trauma, Vaccination
Cite this article as: Nazik S, Orak F, Hakkoymaz H, Şahin HR. Tetanus immunoglobulin G assessment in Adults Trauma Patients. Arch Iran Med. 2020;23(2):99–103.
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Submitted: 12 Apr 2018
Accepted: 21 Oct 2019
ePublished: 01 Feb 2020
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